Figure 1

PAM3 treatment reduces disease severity. (A) C57/BL6 mice were treated with PAM3 (N = 10) or PBS (N = 10) every 2 days and with 2.5% DSS in drinking water daily starting on day 1 and continued through day 9 when they were sacrificed. (B) DAI was assessed daily. (C) Colon lengths were measured on day 9. Data represent the mean ± SD. Untreated controls were included for comparison (N = 5). *p < 0.05; **p < 0.01; ***p < 0.001 for PAM3 versus PBS treated groups. ⁺⁺⁺p < 0.001 for PBS compared to untreated controls.