Table 3 Adverse reactions to LTBI treatment with 9-month treatment with isoniazid.
Total (N = 114) | Completion (n = 71) | Non-completion (n = 43) | P | |
|---|---|---|---|---|
Any adverse reactions | 70 (61.4) | 41(57.7) | 29 (67.4) | 0.422 |
Gastrointestinal | 39 (34.2) | 27 (38.0) | 12 (27.9) | 0.350 |
Nausea | 27 (23.7) | 16 (22.5) | 11 (25.6) | |
Anorexia | 8 (7.0) | 6 (8.5) | 2 (4.7) | |
Diarrhea | 2 (1.8) | 2 (2.8) | 0 (0) | |
Skin | 15 (13.2) | 8 (11.3) | 7 (16.3) | 0.129 |
Itching | 12 (10.5) | 6 (8.5) | 6 (14.0) | |
Urticaria | 4 (3.5) | 1 (1.4) | 3 (7.0) | |
Eczema | 4 (3.5) | 3 (4.2) | 1 (2.3) | |
Hematologic | 21 (18.4) | 13 (18.3) | 8 (18.6) | 0.250 |
Neutropenia | 6 (5.3) | 3 (4.2) | 3 (7.0) | |
Anemia | 12 (10.5) | 7 (9.9) | 5 (11.6) | |
Thrombocytopenia | 4 (3.5) | 3 (4.2) | 1 (2.3) | |
Hepatotoxicity* | 27 (23.7) | 8 (11.3) | 19 (44.2) | <0.001 |
Mild hepatotoxicity | 17 (14.9) | 7 (9.9) | 10 (23.3) | |
Severe hepatotoxicity | 10 (8.8) | 1 (1.4) | 9 (20.9) | |
Peripheral neuropathy | 6 (5.3) | 2 (2.8) | 4 (9.3) | 0.133 |
Others | 39 (34.2) | 26 (36.6) | 13 (30.2) | 0.523 |
Headache | 10 (8.8) | 7 (9.9) | 3 (7.0) | |
Dizziness | 12 (10.5) | 7 (9.9) | 5 (11.6) | |
General weakness | 31 (27.2) | 21 (29.6) | 10 (23.3) | |
Fever | 4 (3.5) | 2 (2.8) | 2 (4.7) |
