Figure 4
Concentrations of NPC2, IGFBP7, and THBS1 in blood samples of HCs and patients with AAAA and TAAA. The concentrations of (A) NPC2 in serum, (B) IGFBP7 in serum, and (C) THBS1 in plasma of 44 HCs, 51 AAAA patients, and 29 TAAA patients were measured using an ELISA kit specific for each protein. (D) ROC analysis of NPC2 (black line), IGFBP7 (black broken line), THBS1 (grey dotted line), or the combination of all three proteins (grey line) in HCs and TAAA patients. The AUCs were 0.933, 0.925, 0.759, and 0.948 for NPC2, IGFBP7, THBS1, and their combination, respectively. (E) ROC analysis of NPC2 (black line), IGFBP7 (black broken line), THBS1 (grey dotted line), or the combination of all three proteins (grey line) between HCs and AAAA patients. The AUCs were 0.828, 0.882, 0.742, and 0.901 for NPC2, IGFBP7, THBS1, and their combination, respectively. HC, healthy control; AAAA, abdominal atherosclerotic aortic aneurysm; TAAA, thoracic atherosclerotic aortic aneurysm; ROC, receiver operating characteristic; AUC, area under the curve.
