Table 2 Biomarker candidates selected by gene ontology terms associated with atherosclerosis and blood vessel function.
Gene symbol | Secretory | Fold change | Protein name | CV (%) | |||
|---|---|---|---|---|---|---|---|
Stage P /NVDC | Stage I /Stage P | NVDC | Stage P | Stage I | |||
ANXA1 | - | 1.88 | 1.71 | Annexin A1 | 33 | 43 | 13 |
ANXA2 |  +  | 1.78 | 1.53 | Annexin A2 | 24 | 32 | 35 |
APOA1 |  +  | 4.02 | 1.41 | Apolipoprotein A-I | 45 | 92 | 33 |
APOA2 |  +  | 2.74 | 1.23 | Apolipoprotein A-II | 50 | 66 | 38 |
APOC1 |  +  | 3.03 | 1.38 | Apolipoprotein C-I | 74 | 53 | 22 |
APOC3 |  +  | 1.13 | 1.83 | Apolipoprotein C-III | 31 | 35 | 18 |
APOE |  +  | 1.64 | 1.61 | Apolipoprotein E | 35 | 50 | 33 |
ATP1A1 | - | 1.01 | 1.77 | Sodium/potassium-transporting ATPase subunit alpha-1 | 19 | 25 | 18 |
ATP5A1 | - | 1.13 | 1.41 | ATP synthase subunit alpha, mitochondrial | 59 | 48 | 34 |
CD44 | - | 1.87 | 1.23 | CD44 antigen | 26 | 50 | 11 |
CDH13 | - | 1.38 | 1.67 | Cadherin-13 | 40 | 37 | 20 |
CLU |  +  | 1.50 | 1.59 | Clusterin | 25 | 42 | 27 |
COL15A1 |  +  | 1.42 | 1.09 | Collagen alpha-1 (XV) chain | 29 | 38 | 19 |
COL1A2 |  +  | 1.05 | 1.67 | Collagen alpha-2 (I) chain | 32 | 40 | 46 |
GNA13 | - | 0.42 | 0.79 | Guanine nucleotide-binding protein subunit alpha-13 | 44 | 34 | 21 |
HEXB | - | 1.27 | 5.42 | Beta-hexosaminidase subunit beta | 12 | 36 | 96 |
IGFBP7 |  +  | 1.46 | 1.23 | Insulin-like growth factor-binding protein 7 | 61 | 51 | 26 |
LBP |  +  | 1.17 | 1.85 | Lipopolysaccharide-binding protein | 27 | 55 | 39 |
NPC2 |  +  | 1.02 | 1.46 | Epididymal secretory protein E1 | 33 | 50 | 32 |
PLCD1 |  +  | 1.02 | 1.41 | 1-Phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1 | 13 | 34 | 30 |
PON1 |  +  | 0.95 | 0.48 | Serum paraoxonase/arylesterase 1 | 36 | 69 | 50 |
RBP4 |  +  | 0.67 | 0.66 | Retinol-binding protein 4 | 32 | 44 | 57 |
SCP2 | - | 1.18 | 1.48 | Non-specific lipid-transfer protein | 26 | 41 | 35 |
SEMA3C |  +  | 1.51 | 1.14 | Semaphorin-3C | 40 | 46 | 33 |
SOD1 | - | 1.18 | 1.45 | Superoxide dismutase [Cu-Zn] | 28 | 42 | 35 |
TGM2 |  +  | 1.56 | 1.67 | Protein-glutamine gamma-glutamyltransferase 2 | 36 | 47 | 38 |
THBS1 |  +  | 1.13 | 1.48 | Thrombospondin-1 | 32 | 39 | 19 |
THY1 | - | 1.99 | 1.28 | Thy-1 membrane glycoprotein | 20 | 42 | 44 |
TNFSF13 |  +  | 2.09 | 1.22 | Tumor necrosis factor ligand superfamily member 13 | 46 | 42 | 38 |