Table 2 Biomarker candidates selected by gene ontology terms associated with atherosclerosis and blood vessel function.

From: Discovery of novel biomarkers for atherosclerotic aortic aneurysm through proteomics-based assessment of disease progression

Gene symbol

Secretory

Fold change

Protein name

CV (%)

Stage P /NVDC

Stage I /Stage P

NVDC

Stage P

Stage I

ANXA1

-

1.88

1.71

Annexin A1

33

43

13

ANXA2

 + 

1.78

1.53

Annexin A2

24

32

35

APOA1

 + 

4.02

1.41

Apolipoprotein A-I

45

92

33

APOA2

 + 

2.74

1.23

Apolipoprotein A-II

50

66

38

APOC1

 + 

3.03

1.38

Apolipoprotein C-I

74

53

22

APOC3

 + 

1.13

1.83

Apolipoprotein C-III

31

35

18

APOE

 + 

1.64

1.61

Apolipoprotein E

35

50

33

ATP1A1

-

1.01

1.77

Sodium/potassium-transporting ATPase subunit alpha-1

19

25

18

ATP5A1

-

1.13

1.41

ATP synthase subunit alpha, mitochondrial

59

48

34

CD44

-

1.87

1.23

CD44 antigen

26

50

11

CDH13

-

1.38

1.67

Cadherin-13

40

37

20

CLU

 + 

1.50

1.59

Clusterin

25

42

27

COL15A1

 + 

1.42

1.09

Collagen alpha-1 (XV) chain

29

38

19

COL1A2

 + 

1.05

1.67

Collagen alpha-2 (I) chain

32

40

46

GNA13

-

0.42

0.79

Guanine nucleotide-binding protein subunit alpha-13

44

34

21

HEXB

-

1.27

5.42

Beta-hexosaminidase subunit beta

12

36

96

IGFBP7

 + 

1.46

1.23

Insulin-like growth factor-binding protein 7

61

51

26

LBP

 + 

1.17

1.85

Lipopolysaccharide-binding protein

27

55

39

NPC2

 + 

1.02

1.46

Epididymal secretory protein E1

33

50

32

PLCD1

 + 

1.02

1.41

1-Phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1

13

34

30

PON1

 + 

0.95

0.48

Serum paraoxonase/arylesterase 1

36

69

50

RBP4

 + 

0.67

0.66

Retinol-binding protein 4

32

44

57

SCP2

-

1.18

1.48

Non-specific lipid-transfer protein

26

41

35

SEMA3C

 + 

1.51

1.14

Semaphorin-3C

40

46

33

SOD1

-

1.18

1.45

Superoxide dismutase [Cu-Zn]

28

42

35

TGM2

 + 

1.56

1.67

Protein-glutamine gamma-glutamyltransferase 2

36

47

38

THBS1

 + 

1.13

1.48

Thrombospondin-1

32

39

19

THY1

-

1.99

1.28

Thy-1 membrane glycoprotein

20

42

44

TNFSF13

 + 

2.09

1.22

Tumor necrosis factor ligand superfamily member 13

46

42

38

  1. NVDC, non-vascular disease control; CV, the coefficient of variance of protein levels in each stage.