Table 2 Summarised meta-analysis results of MBL2 polymorphisms and (R)VVI risk.

From: A meta-analysis of mannose-binding lectin gene polymorphisms with the risk of recurrent vulvovaginal infections

SNP and (R)VVI	Comparisons	Heterogeneity analysis			Effect Model	Egger’s test (p_e)	Begg’s test (p_b)	Overall effect size (Trimmed)			p_c
SNP and (R)VVI	Comparisons	Q-value	P_{heterogeneity}	I² (%)	Effect Model	Egger’s test (p_e)	Begg’s test (p_b)	OR	CI	p-value	p_c
rs1800450 and RVVI	B vs A	50.10	<0.0001	88.02	R	0.002	0.293	3.54	1.69–7.43	0.001	0.005
	BB vs AA	4.96	0.549	0.00	F	0.380	0.176	8.12	2.94–22.4	5.3 × 10⁻⁵	2.6 × 10⁻⁴
	AB vs AA	14.11	0.028	57.49	R	0.348	0.652	3.92	2.05–7.50	4.0 × 10⁻⁵	2.0 × 10⁻⁴
	BB + AB vs AA	12.74	0.047	52.91	R	0.406	0.652	4.54	2.50–8.24	6.9 × 10⁻⁷	3.2 × 10⁻⁶
	BB vs AB + AA	6.24	0.397	3.85	F	0.367	0.176	2.76	1.19–6.37	0.018	0.09
rs1800450 and RVVC	B vs A	34.93	<0.0001	82.82	R	0.012	0.176	3.54	1.79–7.00	2.0 × 10⁻⁴	0.001
	BB vs AA	0.79	0.977	0.00	F	0.910	0.851	12.22	4.09–36.5	7.4 × 10⁻⁶	3.7 × 10⁻⁵
	AB vs AA	13.77	0.032	56.44	R	0.441	0.652	3.97	2.06–7.64	3.7 × 10⁻⁵	1.8 × 10⁻⁴
	BB + AB vs AA	12.44	0.053	51.77	F	0.493	0.652	4.15	2.85–6.06	1.5 × 10⁻¹³	7.5 × 10⁻¹³
	BB vs AB + AA	2.85	0.827	0.00	F	0.270	0.176	3.74	1.61–8.70	0.002	0.01
rs1800450 and RBV	B vs A	3.37	0.066	70.37	F	–	–	1.08	0.79–1.49	0.622	3.11
	BB vs AA	2.58	0.108	61.24	F	–	–	2.69	0.34–21.34	0.350	1.75
	AB vs AA	0.67	0.414	0.00	F	–	–	1.39	0.46–4.21	0.559	2.79
	BB + AB vs AA	1.00	0.316	0.45	F	–	–	1.78	0.64–4.97	0.268	1.34
	BB vs AB + AA	2.05	0.152	51.29	F	–	–	2.34	0.35–15.83	0.384	1.92
rs1800450 and VVI	B vs A	3.92	0.141	49.01	F	0.353	0.117	0.88	0.65–1.19	0.399	1.995
	BB vs AA	0.55	0.758	0.00	F	0.070	0.117	0.25	0.06–0.98	0.046	0.23
	AB vs AA	3.33	0.189	39.94	F	0.335	0.117	1.01	0.72–1.41	0.953	4.765
	BB + AB vs AA	3.84	0.146	47.94	F	0.345	0.117	0.94	0.67–1.31	0.711	3.555
	BB vs AB + AA	0.42	0.810	0.00	F	0.048	0.117	0.25	0.06–0.97	0.045	0.225
rs1800450 and VVC	B vs A	5.81	0.055	65.57	F	0.086	0.117	0.71	0.49–1.01	0.059	0.295
	BB vs AA	0.48	0.788	0.00	F	0.341	0.117	0.61	0.09–4.02	0.604	3.02
	AB vs AA	5.23	0.073	61.75	F	0.104	0.602	0.82	0.55–1.23	0.339	1.695
	BB + AB vs AA	5.89	0.053	66.04	F	0.113	0.602	0.75	0.50–1.11	0.148	0.74
	BB vs AB + AA	0.30	0.862	0.00	F	0.322	0.117	0.30	0.07–1.36	0.118	0.59
rs1800450 and BV	B vs A	1.63	0.201	38.74	F	–	–	0.96	0.60–1.56	0.877	4.385
	BB vs AA	0.27	0.603	0.00	F	–	–	0.64	0.11–3.79	0.623	3.115
	AB vs AA	1.76	0.184	43.22	F	–	–	1.08	0.62–1.89	0.785	3.925
	BB + AB vs AA	1.80	0.179	44.55	F	–	–	1.02	0.59–1.77	0.937	4.685
	BB vs AB + AA	0.42	0.517	0.00	F	–	–	0.66	0.11–3.86	0.641	3.205
Combined Exon1 and RVVI	O vs A	0.03	0.868	0.00	F	–	–	0.96	0.71–1.29	0.785	0.392
	OO vs AA	0.91	0.340	0.00	F	–	–	1.06	0.45–2.49	0.892	4.46
	AO vs AA	1.16	0.282	13.67	F	–	–	0.91	0.63–1.33	0.630	3.15
	OO + AO vs AA	0.50	0.482	0.00	F	–	–	0.93	0.65–1.33	0.686	3.43
	OO vs AO + AA	1.26	0.262	20.60	F	–	–	1.11	0.48–2.58	0.810	4.05
Combined Exon1 and RBV	O vs A	0.05	0.815	0.00	F	–	–	0.95	0.67–1.34	0.771	3.855
	OO vs AA	0.54	0.461	0.00	F	–	–	0.88	0.32–2.38	0.795	3.975
	AO vs AA	0.83	0.362	0.00	F	–	–	0.97	0.63–1.48	0.887	4.435
	OO + AO vs AA	0.42	0.518	0.00	F	–	–	0.96	0.63–1.44	0.827	4.135
	OO vs AO + AA	0.78	0.378	0.00	F	–	–	0.90	0.33–2.41	0.828	4.14

rs1800450 polymorphism (involving A/B allele = G/A allele), combined Exon1 polymorphisms (involving A/O allele = C,G,G/T,A,A alleles of rs5030737, rs1800450 and rs1800451 polymorphisms respectively),R = Random effect model, F = Fixed effect model, p_e = Egger’s test p-value, p_b = Begg’s test p-value, OR = Odds ratio, CI = 95% confidence intervals, p_c = p-value after Bonferroni correction i.e. p-value × 5 genetic models, Bold numbers indicates statistically significant OR values after Bonferroni correction.

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Table 2 Summarised meta-analysis results of MBL2 polymorphisms and (R)VVI risk.

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