Table 1 Summary of statistical significance for the nine EMT transcriptional signatures tested in all conditions for both SK-BR-3 and MDA-MB-231 cells.

From: Fluid shear stress coupled with narrow constrictions induce cell type-dependent morphological and molecular changes in SK-BR-3 and MDA-MB-231 cells

 

SK-BR-3

MDA-MB-231

Non-circulated (control) to circulated (unconfined)

Circulated (unconfined) to constricted

Non-circulated (control) to circulated (unconfined)

Circulated (unconfined) to confined/constricted

Vimentin

 

− (**)

  

E-cadherin

+ (**)

  

− (**)

N-cadherin

  

− (***)

 

Snail1

+ (**)

 

+ (***)

 

Snail2

 

− (***)

  

Twist1

  

− (**)

 

Twist2

+ (**)

 

− (*)

+ (***)

ZEB1

+ (***)

   

ZEB2

+ (*)

 

+ (*)

 
  1. Kolmogorov-Smirnov test was used to compare relative expression of all transcripts in for cell type between two conditions/groups. “+” indicates up-regulation and “−” indicates down-regulation of relative expression of transcript. *Significance level at 0.033; **significance level at 0.002; ***significance level < 0.001; ns, not significant.