Table 6 Distribution of the HLA-DRB1~DQA1~DQB1 haplotypes in individuals with type 1 diabetes mellitus and without T1D.

From: HLA class II genotyping of admixed Brazilian patients with type 1 diabetes according to self-reported color/race in a nationwide study

Haplotypes (DRB1~DQA1~DQB1)

T1D Individuals N (%)

Individuals without T1D N(%)

OR

CI

p value

01:01~01:01 g~05:01

75 (3.68%)

315 (3.08%)

1.2

0.93–1.55

0.16472

01:02~01:01 g~05:01

54 (2.65%)

578 (5.65%)

0.45

0.34–0.60

0.00000

01:03~01:01 g~05:01

4 (0.20%)

67 (0.66%)

0.3

0.11–0.82

0.00970

03:01~05:01 g~02:01

590 (28.95%)

671 (6.56%)

5.8

5.13–6.57

0.00000

03:02~04:01~04:02

10 (0.49%)

306 (2.99%)

0.16

0.08–0.30

0.00000

04:01~03:01 g~03:01 g

11 (0.54%)

74 (0.72%)

0.74

0.39–1.41

0.45982

04:01~03:01 g~03:02

102 (4.99%)

81 (0.79%)

6.6

4.91–8.87

0.00000

04:02~03:01 g~03:02

130 (6.39%)

199 (1.94%)

3.43

2.74–4.31

0.00000

04:03~03:01 g~03:02

7 (0.34%)

33 (0.32%)

1.06

0.47–2.41

0.83218

04:04~03:01 g~03:02

69 (3.39%)

100 (0.98%)

3.55

2.60–4.84

0.00000

04:04~03:01 g~04:02

1 (0.05%)

19 (0.18%)

0.26

0.03–1.97

0.23192

04:05~03:01 g~02:02

11 (0.52%)

17 (0.17%)

3.26

1.52–6.98

0.00352

04:05~03:01 g~03:02

205 (10.06%)

210 (2.05%)

5.34

4.37–6.51

0.00000

04:06~03:01 g~04:02

2 (0.10%)

36 (0.35%)

0.28

0.07–1.16

0.07690

04:07~01:03~06:03

0 (0.00%)

20 (0.20%)

   

04:07~03:01 g~03:01 g

3 (0.15%)

58 (0.57%)

0.26

0.08–0.83

0.00924

04:07~03:01 g~03:02

9 (0.44%)

37 (0.36%)

1.22

0.59–2.54

0.55330

04:08~03:01 g~03:01 g

5 (0.25%)

20 (0.19%)

1.26

0.47–3.35

0.59360

04:11~03:01 g~03:02

14 (0.69%)

258 (2.52%)

0.27

0.16–0.46

0.00000

04:11~03:01 g~04:02

1 (0.05%)

21 (0.20%)

0.24

0.03–1.78

0.15815

07:01~02:01~02:02

125 (6.12%)

1112 (10.87%)

0.54

0.44–0.65

0.00000

07:01~02:01~03:03

4 (0.20%)

166 (1.63%)

0.12

0.04–0.32

0.00000

08:01~04:01~04:02

30 (1.47%)

171 (1.67%)

0.88

0.59–1.30

0.56217

08:02~04:01~04:02

6 (0.29%)

139 (1.36%)

0.21

0.09–0.49

0.00004

08:03~06:01~03:01 g

1 (0.05%)

68 (0.66%)

0.07

0.01–0.53

0.00012

08:04~04:01~03:01 g

9 (0.44%)

66 (0.64%)

0.68

0.34–1.37

0.35046

08:04~04:01~04:02

6 (0.29%)

84 (0.82%)

0.36

0.16–0.82

0.01335

08:07~04:01~04:02

4 (0.20%)

52 (0.51%)

0.38

0.14–1.07

0.06935

09:01~03:01 g~02:02

58 (2.86%)

61 (0.60%)

4.88

3.40–7.02

0.00000

09:01~03:01 g~03:03

11 (0.53%)

82 (0.80%)

0.67

0.36–1.26

0.26463

10:01~01:01 g~05:01

23 (1.13%)

189 (1.84%)

0.61

0.39–0.94

0.02799

11:01~01:02~05:02

1 (0.05%)

51 (0.50%)

0.1

0.01–0.71

0.00210

11:01~01:02~06:02

8 (0.39%)

327 (3.19%)

0.12

0.06–0.24

0.00000

11:01~01:02~06:11

0 (0.00%)

22 (0.22%)

   

11:01~05:01 g~03:01 g

19 (0.93%)

324 (3.16%)

0.29

0.18–0.46

0.00000

11:01~05:10~03:01 g

0 (0.00%)

18 (0.18%)

   

11:02~05:01 g~03:01 g

12 (0.59%)

150 (1.46%)

0.4

0.22–0.72

0.00155

11:02~05:10~03:01 g

1 (0.05%)

24 (0.23%)

0.21

0.03–1.54

0.10735

11:03~05:01 g~03:01 g

5 (0.25%)

50 (0.49%)

0.5

0.20–1.26

0.14891

11:03~05:10~03:01 g

0 (0.00%)

21 (0.20%)

   

11:04~05:01 g~03:01 g

16 (0.79%)

119 (1.16%)

0.67

0.40–1.14

0.16619

12:01 g~01:01 g~05:01

4 (0.20%)

58 (0.57%)

0.34

0.12–0.95

0.02621

12:01 g~05:01 g~03:01 g

12 (0.59%)

35 (0.34%)

1.73

0.89–3.33

0.11396

12:02~01:02~06:02

0 (0.00%)

20 (0.20%)

   

12:02~06:01~03:01 g

0 (0.00%)

35 (0.34%)

   

13:01~01:02~05:01

6 (0.29%)

32 (0.31%)

0.94

0.39–2.25

0.99990

13:01~01:03~06:03

43 (2.11%)

676 (6.60%)

0.3

0.22–0.42

0.00000

13:01~03:01 g~03:03

2 (0.10%)

17 (0.17%)

0.59

0.14–2.56

0.75702

13:02~01:02~05:01

9 (0.44%)

36 (0.35%)

1.26

0.60–2.61

0.54621

13:02~01:02~05:02

3 (0.15%)

15 (0.15%)

1.00

0.29–3.47

0.99480

13:02~01:02~06:04

57 (2.80%)

248 (2.42%)

1.16

0.86–1.55

0.31273

13:02~01:02~06:09

15 (0.74%)

122 (1.19%)

0.61

0.36–1.05

0.08778

13:02~01:03~06:03

1 (0.05%)

34 (0.34%)

0.15

0.02–1.08

0.02212

13:03~02:01~02:02

0 (0.00%)

34 (0.33%)

   

13:03~05:01 g~03:01 g

11 (0.54%)

81 (0.79%)

0.68

0.36–1.23

0.26351

14:02~05:01 g~03:01 g

1 (0.05%)

227 (2.22%)

0.02

0.003–0.15

0.00000

14:04~01:01 g~05:03

4 (0.20%)

18 (0.18%)

1.12

0.38–3.30

0.77609

14:06~05:01 g~03:01 g

3 (0.15%)

43 (0.42%)

0.35

0.11–1.13

0.07289

14:54~01:01 g~05:03

1 (0.05%)

79 (0.77%)

0.06

0.009–0.45

0.00001

15:01~01:02~05:02

2 (0.10%)

18 (0.18%)

0.56

0.13–2.40

0.55981

15:01~01:02~06:02

16 (0.79%)

414 (4.04%)

0.19

0.11–0.31

0.00000

15:02~01:03~06:01

2 (0.10%)

45 (0.44%)

0.22

0.05–0.92

0.01755

15:03~01:02~06:02

18 (0.88%)

503 (4.92%)

0.17

0.11–0.28

0.00000

16:01~01:02~05:02

17 (0.83%)

212 (2.07%)

0.4

0.24–0.65

0.00014

16:02~01:02~05:02

6 (0.29%)

70 (0.68%)

0.43

0.19–0.99

0.04314

16:02~05:01 g~03:01 g

4 (0.20%)

84 (0.82%)

0.24

0.09–0.65

0.00213

Others

159 (7.80%)

660 (6.45%)

1.23

1.03–1.47

0.02560

  1. T1D = type 1 diabetes mellitus; n = number of individuals; OR = odds ratio; CI = confidence interval; sixty-eight haplotypes with total number in patients plus controls greater than 18 were included (0.3%). P required for statistical significance after Bonferroni correction for multiple tests <0.00074. Rare alleles were included in others.
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