Figure 2

Serum parameters in lean and obese mice. Concentrations of cholesterol, HDL, LDL, lipase, CK and GOT were measured in the serum of LFD- and HFD-fed mice from each B6 substrain (n = 8–11; mean ± 95%Cl two-way ANOVA with Sidak’s multiple comparisons test). Concentrations of leptin and FGF21 were measured in the serum using a magnetic bead-based multiplex assay (n = 5–11; mean ± 95%Cl, two-way ANOVA with Sidak’s multiple comparisons test). Two independent experiments were performed.