Figure 1

MC903 treatment initiates an AD-like skin inflammation. Appearance of ethanol- and MC903-treated ears at day 8 (a). Ear thickness of wild type mice treated with EtOH or MC903, measured on day 0 and day 8 (b). Bars are presented as mean + SD; n = 2–7 mice per group (GraphPad Prism v7.0). Hematoxylin and eosin staining of mouse skin treated with EtOH or MC903 analyzed at day 8 (c), black arrows show dermal or epidermal mononuclear leukocyte and granulocyte infiltrates. Scale bar 50 μm.