Figure 2

Representative confocal immunofluorescence images with orthogonal views of different cell types containing α-syn in the AON of human PD OFBs. Small intracellular α-syn inclusions were found in (a) microglia, (b) pericytes and (c) astrocytes. No intracellular α-syn was found in (d) oligodendrocytes. Neurons either contained (e) small α-syn inclusions or (f) large Lewy body like inclusions. Yellow arrows indicate α-syn inclusions that are intracellular. White arrows indicate α-syn inclusions that are extracellular. Scale bar, 10 µm.