Figure 4

Elevated expression of oxidative phosphorylation genes in cluster 1 represents a super-physiologic state. Expression heatmaps of 118 OXPHOG genes following two-way unsupervised hierarchical consensus clustering of TCGA OCSCC. Normal samples are annotated across the top with black boxes and OCSCC muscle contamination determined from Z-scores of ssGSEA values (i.e., from Supplementary Table 11) are annotated horizontally just below. The original OXPHOG cluster of tumors only is also annotated with colored horizontal boxes, and gene function is annotated vertically according to the legend. The ratio of group geometric averages between tumors in cluster 1 and normal samples in cluster 2 is annotated on the left with a vertical bar according to the legend.