Figure 7 | Scientific Reports

Figure 7

From: High expression of oxidative phosphorylation genes predicts improved survival in squamous cell carcinomas of the head and neck and lung

Figure 7

OXPHOG cluster 1 tumors have more favorable baseline tumor immune microenvironments that could explain improved overall survival. Baseline levels of immune subsets present in tumors were estimated through ssGSEA as described in Methods. (A) Cytotoxic cells are significantly more abundant in OCSCC tumors from cluster 1 compared to all other clusters. (B) The proportion of cytotoxic cells to Tregs modeled through combining variables indicated a significantly more favorable ratio in OCSCC tumors from cluster 1. (C) The proportion of CD8 T-cells to Tregs modeled through combining variables indicated a significantly more favorable ratio in OCSCC tumors from cluster 1. (D) The proportion of cytotoxic cells to Tregs modeled through combining variables indicated a significantly more favorable ratio in LUSC tumors from cluster 1. (E) The proportion of CD8 T-cells to Tregs modeled through combining variables indicated a trend in LUSC toward decreasing ratios with increasing OXPHOG cluster number that reached significance between cluster1 and clusters 3–7.

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