Table 1 Significant associations in the trans-breed GWAS.

From: Genome wide association study of 40 clinical measurements in eight dog breeds

Phenotype

SNP

Chr

Position

P value

Experimental-wise p

M value

Human

chr

Human

position(Mb)

Nearest gene

BS

CK

DH

DM

FL

GS

LR

NF

Alanine transaminase

BICF2P496164

13

37,935,521

1.02E-19

≪1E-10

1.000

1.000

0.047

1.000

0.959

0.686

0.884

1.000

8

145.7

GPT, RECQL

Fructosamine

BICF2P1369335

17

61,926,412

2.21E-11

8.85.E-05

0.000

LowMAF

LowMAF

0.062

0.949

1.000

0.000

0.999

1

153.2

LELP1

Stress during physical exam

BICF2P1232291

1

109,530,837

8.25E-09

0.032

0.002

1.000

0.997

NoData

0.001

0.101

0.001

NoData

19

46.7

IGFL1

Morphometric parameter C (height at withers)

BICF2G630361702

3

91,114,590

5.47E-08

0.196

1.000

LowMAF

LowMAF

LowMAF

LowMAF

1.000

LowMAF

0.526

4

18.0

LCORL

Morphometric parameter C (height at withers)

BICF2S22921821

13

31,268,352

7.87E-08

0.270

0.003

0.097

0.987

0.861

0.903

0.999

0.999

0.376

8

136.3

KHDRBS3

C reactive protein

BICF2S2369445

31

15,294,994

1.76E-07

0.505

0.000

0.991

0.015

0.184

LowMAF

0.014

0.000

1.000

21

20.5

 

Erythrocytes

BICF2P751898

32

14,312,867

2.49E-07

0.631

0.982

0.734

0.884

0.305

1.000

0.098

0.092

0.786

4

92.1

CCSER1

Morphometric parameter E (body length)

BICF2P67088

15

41,206,514

2.62E-07

0.649

0.003

LowMAF

1.000

0.501

0.753

LowMAF

0.996

0.201

12

102.8

IGF1

Glucose

BICF2S23023572

36

13,767,189

2.64E-07

0.652

0.999

0.653

0.811

0.700

1.000

0.870

0.926

0.819

2

169.8

ABCB11, G6PC2

Heart rate during clinical examination

BICF2P1178436

7

77,665,554

3.82E-07

0.783

0.219

0.991

1.000

0.249

0.287

LowMAF

0.257

NoData

4

110.6

CCDC109B

Stress during physical exam

BICF2G630755819

36

28,527,094

4.25E-07

0.817

1.000

0.670

0.808

NoData

0.561

0.976

0.829

NoData

2

187.1

 

Morphometric parameter D (maximal chest diameter)

BICF2P200126

12

61,747,626

4.53E-07

0.837

0.001

LowMAF

0.983

0.534

0.004

0.720

1.000

0.499

6

104.7

 

Stress during physical exam

BICF0218038

17

13,896,382

4.61E-07

0.842

0.001

0.973

1.000

NoData

0.658

0.039

0.090

NoData

2

18.8

NT5C1B

  1. Associations with p < 5 × 10−7 is shown. The experimental-wise p values were calculated by the Bonferroni correction with the number of SNPs (n = 100,000) and phenotypes (n = 40). Adjusted P value for Alanine transaminase was not precisely calculated because its value is too smalll. The m-value was obtained using the binary effects model with Metasoft21. The chromosome position is based on CanFam 3.1; m-values > 0.9 suggesting the existence of genetic effect are underlined. BS, Belgian Shepherd; CK, Cavalier King Charles Spaniel; DH, Dachshund; DM, Doberman; FL, Finnish Lapphund; GS, German Shepherd; LR, Labrador Retriever; NF, Newfoundland. “NoData” and “LowMAF” indicate no phenotypic data and an MAF < 0.05 in that breed. The corresponding chromosome position in humans was defined according to hg19.
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