Table 3 The interaction of total urinary arsenic level and inflammasome gene polymorphisms on RCC risk.
Total arsenicb | Polymorphisms of NLRP3 | Case/Control Number | Multivariate ORsa (95% CI) | Pinteraction | S index |
|---|---|---|---|---|---|
Total arsenic | rs12239046 | 0.0219 | 0.66 (0.36–1.23) | ||
<15.6 | T | 93/303 | 1.00§ | ||
<15.6 | C | 179/397 | 1.60 (1.17–2.20) | ||
≥ 15.6 | T | 174/287 | 2.30 (1.65–3.20) | ||
≥ 15.6 | C | 252/413 | 2.26 (1.66–3.09) | ||
Total arsenic | rs10925025 | 0.0172 | 0.66 (0.43–1.01) | ||
<15.6 | A | 92/302 | 1.00§ | ||
<15.6 | G | 180/394 | 1.63 (1.19–2.25) | ||
≥ 15.6 | A | 175/286 | 2.35 (1.68–3.28) | ||
≥ 15.6 | G | 251/408 | 2.31 (1.69–3.17) | ||
Total arsenic | rs1539019 | 0.0116 | 0.65 (0.43–0.98) | ||
<15.6 | A | 91/302 | 1.00§ | ||
<15.6 | C | 181/396 | 1.67 (1.21–2.29) | ||
≥ 15.6 | A | 174/283 | 2.39 (1.71–3.33) | ||
≥ 15.6 | C | 254/415 | 2.33 (1.70–3.19) | ||
Total arsenic | rs10925026 | 0.0187 | 0.66 (0.43–1.01) | ||
<15.6 | C | 92/301 | 1.00§ | ||
<15.6 | A | 180/397 | 1.62 (1.18–2.23) | ||
≥ 15.6 | C | 175/286 | 2.33 (1.67–3.24) | ||
≥ 15.6 | A | 253/412 | 2.29 (1.67–3.13) | ||
Total arsenic | rs10157379 | 0.0250 | 0.67 (0.44–1.04) | ||
<15.6 | C | 93/301 | 1.00§ | ||
<15.6 | T | 179/395 | 1.59 (1.16–2.19) | ||
≥ 15.6 | C | 175/288 | 2.28 (1.64–3.17) | ||
≥ 15.6 | T | 253/412 | 2.26 (1.65–3.08) | ||
Total arsenic | rs12143966 | 0.0721 | 0.74 (0.46–1.18) | ||
<15.6 | G | 109/342 | 1.00§ | ||
<15.6 | A | 161/344 | 1.54 (1.13–2.10) | ||
≥ 15.6 | G | 198/337 | 2.07 (1.52–2.81) | ||
≥ 15.6 | A | 220/357 | 2.19 (1.61–2.96) | ||
Total arsenic | NLRP3 haplotype | 0.5812 | 1.02 (0.50–2.09) | ||
<15.6 | others | 214/600 | 1.00§ | ||
<15.6 | C-A-A-A-A | 58/100 | 1.54 (1.04–2.28) | ||
≥ 15.6 | others | 337/580 | 1.74 (1.38–2.19) | ||
≥ 15.6 | C-A-A-A-A | 91/120 | 2.31 (1.64–3.26) | ||
