Table 3 Genes (raw estimated fold change ≥2, FDR corrected P < 0.05) integrating the oxidative phosphorylation canonical pathway generated by Ingenuity Pathway Analysis (IPA) in comparisons of the early and middle stages and late and middle stages.

From: Long-term high-grain diet alters ruminal pH, fermentation, and epithelial transcriptomes, leading to restored mitochondrial oxidative phosphorylation in Japanese Black cattle

Gene Symbol

Fold change

P-value

Gene Name

Location

Type

Middle vs. Early

Late vs. Middle

Middle vs. Early

Late vs. Middle

ATP5F1C

−3.39

2.16

2.38.E-04

3.86.E-05

ATP synthase F1 subunit gamma

Cytoplasm

Transporter

ATP5F1B

−2.16

 

7.60.E-04

 

ATP synthase F1 subunit beta

Cytoplasm

Transporter

ATP5PO

 

2.05

 

4.86.E-05

ATP synthase peripheral stalk subunit OSCP

Cytoplasm

Transporter

ATPAF1

−3.40

3.94

4.75.E-04

6.83.E-06

ATP synthase mitochondrial F1 complex assembly factor 1

Cytoplasm

Other

COX11

 

2.33

 

2.69.E-04

cytochrome c oxidase copper chaperone COX11

Cytoplasm

Enzyme

NDUFA6

 

−4.22

 

2.33.E-08

NADH:ubiquinone oxidoreductase subunit A6

Cytoplasm

Enzyme

NDUFA9

−2.06

 

4.26.E-04

 

NADH:ubiquinone oxidoreductase subunit A9

Cytoplasm

Enzyme

NDUFAB1

 

2.02

 

3.42.E-04

NADH:ubiquinone oxidoreductase subunit AB1

Cytoplasm

Enzyme

NDUFS1

−3.20

3.07

2.89.E-05

1.95.E-08

NADH:ubiquinone oxidoreductase core subunit S1

Cytoplasm

Enzyme

NDUFS6

−2.22

 

2.40.E-03

 

NADH:ubiquinone oxidoreductase subunit S6

Cytoplasm

Enzyme

NDUFV3

−2.06

2.18

7.68.E-03

3.07.E-03

NADH:ubiquinone oxidoreductase subunit V3

Cytoplasm

Enzyme

SDHA

−7.32

7.18

2.73.E-06

2.14.E-10

succinate dehydrogenase complex flavoprotein subunit A

Cytoplasm

Enzyme

SDHB

−3.18

3.57

4.64.E-04

9.90.E-06

succinate dehydrogenase complex flavoprotein subunit B

Cytoplasm

Enzyme

SDHC

−3.42

2.78

3.90.E-05

1.27.E-07

succinate dehydrogenase complex flavoprotein subunit C

Cytoplasm

Enzyme

UQCRC1

−4.71

3.57

1.78.E-04

1.42.E-05

ubiquinol-cytochrome c reductase core protein 1

Cytoplasm

Enzyme

UQCRQ

 

−2.25

 

1.86.E-05

ubiquinol-cytochrome c reductase complex III subunit VII

Cytoplasm

Enzyme