Figure 7 | Scientific Reports

Figure 7

From: Development of a new macrophage-specific TRAP mouse (MacTRAP) and definition of the renal macrophage translational signature

Figure 7The alternative text for this image may have been generated using AI.

Comprehensive gene set enrichment analysis (GSEA) based on the top 300 overrepresented genes in kidney macrophages (MacTRAP bound fractions) using Enrichr. (A–C) GSEA for cell types and tissue reveals significant overrepresentation of immune-related terms including “macrophage”, “alveolar macrophage”, “dendritic cell”, “macrophage_bone_marrow_0hr” and “monocyte”. (D , E) GSEA for molecular function and cellular component gene ontologies demonstrate enrichment for terms such as “actin binding”, “actin filament binding”, “phagocytic vesicle” and “microfilament motor activity”. (F–I) GSEA for various signaling and metabolic pathways identifies terms such as “immune system”, “microglia pathogen phagocytosis pathway”, “macrophage markers”, “phagosome” and “inflammation mediated by chemokine and cytokine signaling pathway”. Bar graphs show enriched terms sorted by p value ranking.

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