Figure 4
From: Hepatocyte-specific deletion of Pparα promotes NAFLD in the context of obesity
PPARα-independent changes in hepatic gene expression profiles in response to HFD. WT, Pparαhep−/−, and Pparα−/− mice were fed a control diet (CTRL) or a HFD for 10 weeks at 30 °C (thermoneutrality). (a) Venn diagram presenting the number of hepatic genes over-expressed (bold) and down-regulated (regular) in response to HFD in WT, Pparαhep−/−, Pparα−/− mice (FDR < 5%) (b) Grey bars represent the top 15 specifically induced and repressed genes between WT exposed to CTRL diet and WT exposed to HFD. Red and blue bars represent the profile in Pparαhep−/− and Pparα−/− mice, respectively. (c) Gene Ontology (GO) enrichment analysis (p ≤ 0.01) of KEGG categories based on functional interactions specifically down-regulated in WT mice fed a HFD using the String database. (d) Gene Ontology (GO) enrichment analysis (adjusted p-value; p ≤ 0.01) of KEGG categories (based on functionally interactions) up-regulated in WT mice fed a HFD the using string database.
