Figure 5
From: Hepatocyte-specific deletion of Pparα promotes NAFLD in the context of obesity
Hepatocyte PPARα prevents liver inflammatory gene expression in response to HFD. WT, Pparαhep−/−, and Pparα−/− mice were fed a control diet (CTRL) or a HFD for 10 weeks at 30 °C (thermoneutrality). (a) Venn diagram highlighting the number of hepatic genes over-expressed (bold) and down-regulated (regular) in response to HFD specifically in both Pparαhep−/− and Pparα−/− mice (FDR < 5%). (b) Gene Ontology (GO) enrichment analysis (adjusted p ≤ 0.01) of KEGG categories specifically up-regulated in both Pparαhep−/− and Pparα−/− mice fed a HFD. (c) Gene expression profile of genes identified as being involved in NF-kappa B, TNF and TLR signalling pathways in KEGG.
