Table 3 Pharmacokinetic properties of compounds 9-23, 30 and 31.
Comp. | Ar | Exp. Log P | TPSA(Å) | MW | nON | nOHNH | nviolat. | nrot | %ABS |
|---|---|---|---|---|---|---|---|---|---|
9 |
| 1.59 | 48.02 | 393 | 5 | 0 | 0 | 3 | 92.43 |
10 |
| 1.44 | 57.26 | 423 | 6 | 0 | 0 | 4 | 89.24 |
11 |
| 0.23 | 65.10 | 421 | 6 | 0 | 0 | 4 | 86.54 |
12 |
| 1.48 | 48.02 | 443 | 5 | 0 | 0 | 3 | 92.43 |
13 |
| 1.26 | 48.02 | 411 | 5 | 0 | 0 | 3 | 92.43 |
14 |
| 1.63 | 48.02 | 399 | 5 | 0 | 0 | 3 | 92.43 |
15 |
| 1.54 | 48.02 | 407 | 5 | 0 | 0 | 3 | 92.43 |
16 |
| 1.74 | 48.02 | 421 | 5 | 0 | 0 | 4 | 92.43 |
17 |
| 1.41 | 65.10 | 435 | 6 | 0 | 0 | 4 | 86.54 |
18 |
| 1.34 | 48.02 | 427 | 5 | 0 | 0 | 3 | 92.43 |
19 |
| 2.05 | 48.02 | 472 | 5 | 0 | 0 | 3 | 92.43 |
20 |
| 1.88 | 57.26 | 423 | 6 | 0 | 0 | 4 | 89.24 |
21 |
| 1.77 | 48.02 | 411 | 5 | 0 | 0 | 3 | 92.43 |
22 |
| 1.37 | 48.02 | 399 | 5 | 0 | 0 | 3 | 92.43 |
23 |
| 1.67 | 48.02 | 461 | 5 | 0 | 0 | 4 | 92.43 |
30 |
| 2.16 | 65.85 | 515 | 7 | 0 | 1 | 4 | 86.28 |
31 |
| 1.77 | 65.85 | 515 | 7 | 0 | 1 | 4 | 86.28 |
