Table 2 Prediction of the MHC-II T-cell epitopes.

From: In-silico identification of the vaccine candidate epitopes against the Lassa virus hemorrhagic fever

Epitope	Sequence	Interval	Prediction Method			Antigenicity
Epitope	Sequence	Interval	ProPred	NetMHCII 2.3	EpiTOP 3.0	Antigenicity
E5	MGQIVTFFQ	1–9	✓	×	✓	−0.1820
E6	VYELQTLEL	65–73	✓	×	✓	0.8600
E7	LNMTMPLSC	78–86	✓	×	✓	0.9390
E8	INHKFCNLS	113–121	✓	×	✓	1.5060
E9	*MSIISTFHL*	134–142	✓	✓	✓	0.7080
	LYDHALMSIISTFHL	128–142	×	✓	×	0.2896
	YDHALMSIISTFHLS	129–143	×	✓	×	0.4907
	DHALMSIISTFHLSI	130–144	×	✓	×	0.4809
	HALMSIISTFHLSIP	131–145	×	✓	×	0.1949
	ALMSIISTFHLSIPN	132–146	×	✓	×	0.2066
	LMSIISTFHLSIPNF	133–147	×	✓	×	0.2428
E10	FNQYEAMSC	147–155	✓	×	✓	0.5520
E11	ISVQYNLSH	162–170	✓	×	✓	1.1310
E12	LQTFMRMAW	188–196	✓	✓	×	0.2620
	VANGVLQTFMRMAWG	183–197	×	✓	×	0.1328
	ANGVLQTFMRMAWGG	184–198	×	✓	×	0.1683
	NGVLQTFMRMAWGGS	185–199	×	✓	×	0.0579
	GVLQTFMRMAWGGSY	186–200	×	✓	×	0.1572
	VLQTFMRMAWGGSYI	187–201	×	✓	×	0.1895
E13	*MRMAWGGSY*	192–200	✓	✓	✓	0.7630
	GVLQTFMRMAWGGSY	186–200	×	✓	×	0.1572
	VLQTFMRMAWGGSYI	187–201	×	✓	×	0.1895
	LQTFMRMAWGGSYIA	188–202	×	✓	×	0.1902
	QTFMRMAWGGSYIAL	189–203	×	✓	×	0.3470
	TFMRMAWGGSYIALD	190–204	×	✓	×	0.4434
	FMRMAWGGSYIALDS	191–205	×	✓	×	0.3543
E14	YQYLIIQNT	217–225	✓	✓	×	0.4720
	DCIMTSYQYLIIQNT	211–225	×	✓	×	0.6600
	CIMTSYQYLIIQNTT	212–226	×	✓	×	0.7075
	IMTSYQYLIIQNTTW	213–227	×	✓	×	0.6029
	TSYQYLIIQNTTWED	215–229	×	✓	×	0.6874
E15	LIIQNTTWE	220–228	✓	×	✓	0.9100
E16	IGYLGLLSQ	239–247	✓	×	✓	1.5300
E17	LLSQRTRDI	244–252	✓	×	✓	1.7310
E18	IYISRRRRG	252–260	✓	✓	×	1.5560
	SQRTRDIYISRRRRG	246–260	×	✓	×	1.6434
	QRTRDIYISRRRRGT	247–261	×	✓	×	1.5276
	RTRDIYISRRRRGTF	248–262	×	✓	×	1.7213
	TRDIYISRRRRGTFT	249–263	×	✓	×	1.4112
	RDIYISRRRRGTFTW	250–264	×	✓	×	1.5207
	DIYISRRRRGTFTWT	251–265	×	✓	×	1.4261
	IYISRRRRGTFTWTL	252–266	×	✓	×	1.2680
E19	WMLIEAELK	283–291	✓	×	✓	1.3250
E20	IQLINKAVN	334–342	✓	×	✓	0.7710
E21	LINDQLIMK	344–352	✓	×	✓	−0.0481
E22	LRDIMCIPY	355–363	✓	×	✓	1.0590
E23	LVSNGSYLN	387–395	✓	×	✓	0.3450

The epitopes predicted by all three methods are highlighted in boldface with Italic font. The consensus core regions highlighted in boldface are in the epitopes predited by NetMHCII 2.3.

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Table 2 Prediction of the MHC-II T-cell epitopes.

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