Figure 4
The correlations between inflammation score and the numbers of hyperplastic and neoplastic lesions per rat at 96 weeks. One point corresponds to the score of one rat. (a) Neutrophil infiltration in the alveolar wall; (b), neutrophil infiltration in the alveolar space; (c), lymphocyte infiltration in the alveolar space; (d), macrophage infiltration in the alveolar space; (e), pulmonary oedema; (f), pulmonary fibrosis; (g), granuloma; (h), lymph follicle formation around the bronchiole; (i), total score. R = Spearman’s correlation coefficient, P = P value. *Significant correlations with number of hyperplasia. #Significant correlations with number of adenomas. †Significant correlations with number of adenocarcinomas. The following show significant differences in each combination. c*: R = 0.47, P = 0.01; c#: R = 0.53, P = 0.01; c†: R = 0.56, P = 0.002; d#: R = 0.40, P = 0.05; e*: R = 0.69, P = 0.0001; f*: R = 0.50, P = 0.01; f#: R = 0.46, P = 0.02; h*: R = 0.61, P = 0.001; h#: R = 0.50, P = 0.01; h†: R = 0.45, P = 0.02; i*: R = 0.69, P = 0.0001; i#: R = 0.57, P = 0.002.
