Figure 3 | Scientific Reports

Figure 3

From: Effects of anti-PD-1 immunotherapy on tumor regression: insights from a patient-derived xenograft model

Figure 3

Anti-PD-1 administration is associated with an acute inflammatory reaction. (A) Shown is a representative patient-derived xenograft PDX4 tumor treated with anti-PD-1 monotherapy, characterized by the formation of a fluid exudate. (B) Shown is a representative example of a mouse in the anti-PD-1 + cisplatin (concomitant) treatment group, presenting ‘wet hair’ caused by the exudate of the subcutaneous tumor – the ‘wet hair’ image is also zoomed. (C) Liquid cytology (ThinPrep, Cytyc Corporation; Boxborough, MA, USA) of the exudate showing dead epithelial cells (pink arrows) and cell debris from necrotic tissue and also inflammatory cells such as polymorphonuclear cells (blue arrows), and macrophages (green arrows), magnification ×20. (D) Liquid cytology of polymorphonuclear cells, magnification ×75.

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