Figure 6
Mammary gland development analysis. Representative whole mount analysis of mammary gland structure from WT (FVB/NJ; a,c,e,g,i) or mutant (Sprn0/0, b,d,f,h,j) mice. It highlights defects in duct tree formation in 6-week-old virgin, in duct side-branching during early gestation (G7,5) and consequently in the density and organization of the mammary epithelium during lactation (L2: day 2 of lactation, 10: day 10 of lactation; +pups: in the presence of pups, −pups: in the absence of pups). Bar = 0.5 mm. Enlarged views of each developmental stage show the differences in mammary epithelial tissue organization between WT and Sprn0/0 mice. Bar = 200 nm.
