Figure 5

Description of biological network response. (A,B) Stimulus intensity and network responses. Statistics of the pooled normalized SNRs (obtained dividing by the max SNR in each experiment) across all the experiments (N = 12) obtained in time bin T of 500 (A) and 50 (B) milliseconds following the stimulations. (A1,B1) Normalized SNRs as function of the stimulus intensity is shown over the all ranges (left) and a zoom of the gray area (where a linearity of response can be observed) is shown on the right plot. (A2,B2) Histograms showing the distributions of the responses. Note that although responses are distributed across the all range of response, most of the responses follow within the linear regime highlighted in gray in A1 and B1. (C–G) Information processing, response time and linearity of response. The analysis shown in C-G is for a representative experiment (experiment # 9 of Fig. 3). Supp. Fig. 6 report the same analysis for all other experiments. (C) Heatmap of the information transmission (maxIT) varying the response bin size T (between 10 and 500 ms in bins of 10) and the threshold on the SNRs (threshold is between 100 and 5000 spikes in bins of 50). (D) The maximal information transmission is obtained with T = 90 ms and for a threshold of 200 spikes (red dot in the heatmap of C). In the plot of the SNR as function of stimulus intensity, the responses below threshold are shown in red. (E) SOPs as functions SIPs (with T = 90 ms) is shown for all responses (blue) and for the ones below threshold (red). (F) Maximal information transmission as a function of the bin size T (calculated as shown in C-G) across the 12 experiments. (G) Maximal information transmission (same as D) as a function of the linearity of the SNR (which quantify the correlation between SNR and stimulus intensity). Linearity was calculated in the time bin T and SNR threshold optimizing the information transmission.