Figure 1

Classification of microbial sequences supported by cell-free DNA. Results of sputum microbiological culture and cfDNA testing of concordantly collected blood specimens are shown for relevant organisms. Culture results are reported according to standard 1+ to 4+ notation. cfDNA p-values were determined by Grubb’s Test for Outliers, with only values significant at p < 6×10⁻⁴ (the Bonferroni critical value for uncorrected p = 0.05) and supported by 2 or more reads considered valid.