Figure 5 | Scientific Reports

Figure 5

From: Long-term potentiation prevents ketamine-induced aberrant neurophysiological dynamics in the hippocampus-prefrontal cortex pathway in vivo

Figure 5

LTP induction prevents Ketamine effects. (A) LTP prevents the increase in MI state caused by ketamine. Averaged MI across the entire recording in KET (n = 7) and LTP-KET (n = 9) groups (left). Comparison of the baseline normalized MI in the initial 30 min after ketamine injection. There is a significant decrease in delta-high-gamma CFC when ketamine is preceded by HFS. (B) 3D plot of the Principal Component Analysis of electrophysiological features in the KET and LTP-KET groups. A quadratic discriminant function was used to classify each 5 min epochs after ketamine injection indicating separation on the training (filled circles) and test (open triangles) PFC LFPs (cross-validation accuracy: 85.56%). (C) Explained variance of the Principal Components. (D) PC score of the KET and LTP-KET epochs (left) and correlation coefficients between variables and PCs. This data indicates that KET and LTP-KET have a clear distinct electrophysiological feature. While KET epochs are described by the presence of delta, high-gamma, increased CFC and fPSP, HFS-KET epochs are characterized by the presence of theta power, elevation of high-gamma power and a reduction of fPSP. *(p < 0.05).

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