Figure 4

Protein expression in NT, Hyp/Pap PDSCC and WDSCC tissue cores. Tissue arrays were stained for MMP7, c-Myc, FRA1 and Cyclin D1. Tissue core images were thresholded for the amount of stain per amount of tissue for each tissue core (AFperAMT). Mountain plots (left) were constructed to show the protein expression for each tissue core with EpSCC tissue cores shown by red bars and normal tissue cores shown by green bars. A box plot of the AFperAMT in tumour and tumour adjacent cores was constructed to illustrate the change in expression in tumour tissue (right). Significance is represented by a * (Mann Whitney U, ****p < 0.0001, ***p < 0.001, **p < 0.005, *p < 0.05).