Table 1 Comparison of clinical and laboratory parameters according to KDPI score and the age of KTRs.

From: Impact of Kidney Donor Profile Index Scores on Post-Transplant Clinical Outcomes Between Elderly and Young Recipients, A Multicenter Cohort Study

Variables

Low KDPI- young KT

Low KDPI- elderly KT

High KDPI-young KT

High KDPI-elderly KT

p for Trend

Donors

n = 239

n = 30

n = 196

n = 61

 

   Age at KT (years)

35.6 ± 12.3

34.2 ± 12.5

53.8 ± 8.9

59.1 ± 7.5

<0.001

   Gender (Male: Female)

173: 66

24: 6

132: 64

39: 22

0.292

   Body mass index (kg/m2)

23.0 ± 4.1

23.3 ± 3.7

23.2 ± 3.3

22.9 ± 2.7

0.457

   Hypertension, n (%)

9 (3.8)

2 (6.7)

76 (38.8)

20 (32.8)

<0.001

   Diabetes mellitus, n (%)

6 (2.5)

0

34 (17.3)

10 (16.4)

<0.001

   Cause of donor death - CVA, n (%)

151 (63.2)

16 (53.3)

145 (74.0)

51 (83.6)

0.001

   Baseline GFR (ml/min/1.73m2) (CKD-EPI)

116.7 ± 35.7

117.9 ± 44.9

117.7 ± 28.7

118.9 ± 30.0

0.726

   Acute kidney injury, n (%)

95 (39.7)

18 (60.0)

141 (71.9)

39 (63.9)

<0.001

Recipients

n = 285

n = 34

n = 262

n = 76

 

   Transplant year, n (%)

    

0.012

   1996 ~ 2005

8 (2.8)

0

0

0

 

   2006 ~ 2010

51 (17.9)

3 (8.8)

37 (14.1)

4 (5.3)

 

   2011 ~ 2017

226 (79.3)

31 (91.2)

225 (85.9)

72 (94.7)

 

Age at KT (yr)

45.7 ± 8.4

63.7 ± 2.7

47.8 ± 8.5

63.6 ± 3.2

<0.001

   Gender (Male: Female)

168: 117

20: 14

155: 107

46: 30

0.997

   Body mass index (kg/m2)

22.9 ± 4.1

23.9 ± 3.1

23.4 ± 3.6

23.1 ± 3.1

0.312

   Hypertension, n (%)

232 (81.4)

31 (91.2)

224 (85.5)

66 (86.8)

0.348

   Diabetes mellitus, n (%)

46 (16.1)

9 (26.5)

64 (24.4)

18 (23.7)

0.063

   Dialysis duration, years

9.0 ± 9.0

7.0 ± 3.7

8.2 ± 13.0

6.9 ± 4.3

0.355

   Previous KT, n (%)

41 (14.4)

4 (11.8)

22 (8.4)

3 (3.9)

0.023

Cause of ESRD, n (%)

    

<0.001

   Glomerulonephritis

149 (52.3)

7 (20.6)

104 (39.7)

38 (50.0)

 

   Diabetes mellitus

35 (12.3)

9 (26.5)

51 (19.5)

19 (25.0)

 

   Hypertension

37 (13.0)

8 (23.5)

60 (22.9)

10 (13.2)

 

   Others

64 (22.5)

10 (29.4)

47 (17.9)

9 (11.8)

 

   Cold ischemic time (min)

255.3 ± 127.4

245 .2 ± 149.9

246.0 ± 119.3

254.9 ± 117.1

0.836

   HLA mismatch number

3.5 ± 1.5

3.4 ± 1.6

3.8 ± 1.5

3.8 ± 1.5

0.101

Induction, n (%)

    

0.045

   Basiliximab

217 (76.1)

22 (64.7)

174 (66.4)

50 (65.8)

 

   Anti-thymocyte globulin

68 (23.9)

12 (35.3)

88 (33.6)

26 (34.2)

 

Main immunosuppressant, n (%)

     

   Tacrolimus: Cyclosporine

278: 6

34: 0

259: 3

76: 0

0.733

   PRA > 50%

32 (19.5)

4 (20.0)

27 (13.9)

6 (15.4)

0.491

  1. Values are expressed as means ± SDs, n (%).
  2. KDPI, kidney donor profile index; KTR, kidney transplant recipient; CVA, cerebrovascular accident; ESRD, end-stage renal disease, HLA, human leukocyte antigen; PRA, panel reactive antibody.
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