Figure 3 | Scientific Reports

Figure 3

From: Microencapsulated Insulin-Like Growth Factor-1 therapy improves cardiac function and reduces fibrosis in a porcine acute myocardial infarction model

Figure 3

(A) Microphotographs of Picrosirius red staining under polarized light optical microscopy showing the CVF differences in myocardial scar among CON (n = 7), MSPs (n = 7) and IGF-1 MSPs (n = 7) groups. At the bottom of panel A histogram of the CVF analysis in infarct zone in CON (n = 7), MSPs (n = 7) and IGF-1 MSPs (n = 7). CVF was significantly lower in IGF-1 MSPs compared to CON and MSPs (p = 0.005 and p = 0.029, respectively; Tukey HSD Test). Scale bar = 50 μm. (B) Vascular area analysis. Representative images from CON (n = 7), MSPs (n = 6) and IGF-1 MSPs (n = 8) groups of remote zones after Isolectin B4 (green) immunostaining. At the bottom, histogram of the vascular area (%) analysis in remote zone of the three study groups. Vessel density in remote myocardium was significantly higher in IGF-1 MSPs in comparison to CON (p = 0.019; Tukey HSD Test). Scale bar = 50 μm.

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