Figure 6 | Scientific Reports

Figure 6

From: Nucleic acid recognition and antiviral activity of 1,4-substituted terphenyl compounds mimicking all faces of the HIV-1 Rev protein positively-charged α-helix

Figure 6

Effect of terphenyls 1a, 1d and 3c on HIV-1 RNA splicing and LTR-dependent gene expression. (A) Relative quantities (RQ) of unspliced, single-spliced and multiple-spliced HIV-1 RNA transcripts in cells treated with two concentrations of 1a, 1d or 3c. The image shows transcript quantities measured at 48 hours after infection, using transcript levels obtained from untreated cells as a reference (RQ = 1). (B) Inhibition of HIV-1 LTR-dependent gene expression as a function of terphenyl concentration. The results are expressed as a percentage of relative luminescence units (RLUs), where 100% is the luminescence level obtained in the presence of the vehicle used to dissolve the compounds.

Back to article page