Table 3 Results of cellular assays for 1,4-terphenyl compounds. Inhibitory activity (EC50) in experiments based on infection with HIV virus and transfection with HIV- and LTR-dependent vectors, and cellular toxicity (CC50).
Compounda | EC50 infection HIV-1 (μM) | EC50 transfection HIV-1 (μM) | EC50 transfection HIV-1 LTR (μM) | EC50 transfection HTLV LTR (μM) | CC50 (μM) |
|---|---|---|---|---|---|
1a | 10.6 (5.55–20.2, 0.9532) | 12.2 (5.40–25.5, 0.8597) | 7.20 (3.70–13.1, 0.6652) | 16.7 (3.67–87.9, 0.7222) | >100 |
1b | >100 | n/d | n/d | n/d | >100 |
1c | >100 | n/d | n/d | n/d | >100 |
1d | 57.9 (29.5–114, 0.7791) | 6.00 (3.30–10.9, 0.8275) | 3.20 (0.950–6.82, 0.9513) | 24.9 (10.8–59.4, 0.7312) | >100 |
2a | >100 | n/d | n/d | n/d | >100 |
2b | >100 | n/d | n/d | n/d | >100 |
3a | 35.5 (7.39–840, 0.8834) | n/d | n/d | n/d | >100 |
3b | >100 | n/d | n/d | n/d | >100 |
3c | 14.1 (8.5–23.5, 0.9707) | 15.4 (6.80–33.8, 0.8178) | 3.32 (1.19–6.60, 0.9645) | 16.4 (3.88–82.4, 0.7578) | >100 |
4 | >50 < 100 | n/d | n/d | n/d | >100 |
