Table 2 Characteristics from patients suffering from trigeminal neuropathic pain derived from the available eligible publications (non-imputed data).

From: Motor cortex stimulation in chronic neuropathic orofacial pain syndromes: a systematic review and meta-analysis

 

Ref.

Article type

N

Sex M/F

Mean age (years)

Diagnoses

Mean duration of pain (years)

Mean preoperative VAS

Mean VAS at last follow-up

Mean period of follow-up (months)

Mean pain relief after iMCS (%)

Cases with significant pain control (%)

Complications (%)

Neurological

Other

1

55

Retrospective analysis

9

1/8

57.1 ± 13.8

3;7;8;9;11

4.1 ± 3.4

—

—

—

85.6 ± 8.8

100

—

—

2

44

Observational study

7

5/2

52.6 ± 25.3

8;13

13.8 ± 8.5

8.5 ± 0.6

2.3 ± 3.3

121.2 ± 35.4

69.2 ± 38.0

83.3

28.6

42.9

3

10

Observational study

7

1/6

55.4 ± 15.3

1;7

10.6 ± 9.5

—

—

14.5 ± 0.0

77.5 ± 38.6

75.0

14.3

0.0

4

78

Observational study

9

5/4

59.3 ± 11.0

3;7;12;13

—

8.7 ± 1.8

3.4 ± 2.4

10.0 ± 0.0

63.3 ± 28.4

85.7

—

—

5

43

Observational study

5

1/4

58.2 ± 15.5

1

—

9.8 ± 0.5

3.5 ± 1.3

3.0 ± 0.0

54.2 ± 24.9

80

20.0

0.0

6

75

RCT

7

1/6

58.9 ± 16.6

4;6;7;9;12;15

11.4 ± 15.5

9.5 ± 0.7

—

—

42.6 ± 34.8

60.0

0.0

14.3

7

79

Observational study

7

2/5

52.1 ± 12.4

4;11;13

—

7.7 ± 0.5

2.6 ± 2.3

—

67.1 ± 28.3

85.7

0.0

14.3

8

47

Retrospective analysis

10

0/10

64.1 ± 10.1

1;4;9;12

6.3 ± 3.3

8.0 ± 0.0

5.5 ± 3.0

4.2 ± 3.5

36.1 ± 29.8

50

—

—

9

84

Retrospective analysis

8

4/4

48.4 ± 7.4

9;13

—

7.2 ± 1.2

5.4 ± 1.7

13.1 ± 15.0

24.6 ± 22.4

12.5

37.5

12.5

10

13

Observational study

5

3/2

54.6 ± 17.8

3;11;13

3.5 ± 0.7

—

—

54 ± 5.7

47.5 ± 46.0

50

—

—

11

81

Retrospective analysis

7

3/4

53.3 ± 7.4

3;9;10;11;13

—

8.1 ± 1.6

3.0 ± 1.7

21.6 ± 3.3

63.2 ± 15.8

100

—

—

12

83

Retrospective analysis

11

3/8

47.4 ± 13.0

1;4;9;10;11;12

4.7 ± 3.3

—

-

31.6 ± 21.2

100 ± 0.0*

100

—

—

13

77

Double-blinded crossover trial

4

2/2

53.8 ± 18.1

11;13

3.75 ± 2.2

—

—

—

66.3 ± 45.0

75

—

—

14

9

Observational study

3

1/2

71.3 ± 15.0

3;10;11

6.7 ± 4.0

—

—

31.0*

55.0*

100

0.0

33.3

15

82

Observational study

3

2/1

61.3 ± 21.0

7;14

9.3 ± 1.2

9.0*

0.0*

—

87.7 ± 11.0

100

66.7

33.3

16

86

Observational study

14

6/8

58.9 ± 7.3

2;4;9;10;11;12

8.7 ± 6.5

8.9 ± 1.1

10.2 ± 18.9

36.0 ± 0

40 ± 28.9

42.9

7.1

7.1

17

42

Retrospective analysis

5

3/2

53.0 ± 11.4

11

—

—

—

—

75.0 ± 10.0

100.0

20

0.0

18

24

Case report

2

0/2

51.5 ± 12.0

5;12

15.0*

7.5 ± 0.7

2.5 ± 0.7

44.5 ± 46.0

66.0 ± 12.7

100.0

50.0%

0.0

19

40

Retrospective analysis

2

0/2

61.0 ± 4.2

2

7.0 ± 1.4

8.5 ± 0.7

6.5 ± 3.5

182.0 ± 110.3

25.0 ± 35.4

50.0

0.0

0.0

20

45

Observational study

10

3/7

51.2 ± 8.6

10;11;13

6.3 ± 3.9

—

—

—

 

0.0*

0.0

0.0

21

76

Observational study

2

1/1

47.5 ± 6.4

7;11

3.9 ± 4.4

10.0 ± 0.0

3.0 ± 1.4

—

70.0 ± 14.1

100.0

—

—

22

85

Retrospective analysis

2

1/1

70.5 ± 12.0

14

6.9 ± 0.1

9.0 ± 0.0

8.5 ± 0.7

25.0 ± 4.2

6.25 ± 8.8

100.0

—

—

23

80

Case report

1

0/1

54.0

13

14.0

10.0

7.0

5.0

30.0

100.0

0.0

0.0

  1. 1 = Anesthesia dolorosa; 2 = Atypical facial pain; 3 = Brainstem lesion; 4 = Dental avulsion pain; 5 = Glossopharyngeal neuralgia; 6 = Neurofibromatosis type 1; 7 = Post-herpetic neuropathic pain; 8 = Post-neurosurgical pain; 9 = Post-surgical pain; 10 = Post-traumatic pain; 11 = Symptomatic trigeminal neuralgia; 12 = Trigeminal neuralgia; 13 = Trigeminal neuropathic pain; 14 = Trigeminal deafferentation pain; *= limited subjects in subanalysis due to missing information; VAS = Visual analogue scale; − = Missing.
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