Table 1 Echocardiographic parameters of sham and TAC mice.

From: The Synthetic Curcumin Analogue GO-Y030 Effectively Suppresses the Development of Pressure Overload-induced Heart Failure in Mice

Parameter

Sham

TAC

Vehicle

Vehicle

CUR 1 mg/kg

CUR 50 mg/kg

GO-Y030 0.1 mg/kg

GO-Y030 0.5 mg/kg

LVPWd (mm)

1.05 ± 0.12

1.73 ± 0.17**

1.69 ± 0.09

1.43 ± 0.05##

1.62 ± 0.11

1.31 ± 0.09##††

IVSd (mm)

1.24 ± 0.11

1.63 ± 0.12**

1.62 ± 0.15

1.39 ± 0.11#

1.53 ± 0.09

1.38 ± 0.09##†

LVIDd (mm)

2.67 ± 0.26

2.83 ± 0.42

2.72 ± 0.31

2.66 ± 0.21

2.71 ± 0.22

2.67 ± 0.25

LVIDs (mm)

1.20 ± 0.27

1.81 ± 0.23**

1.71 ± 0.27

1.30 ± 0.21##

1.50 ± 0.36

1.27 ± 0.26##

LVMI (g/mg)

4.1 ± 0.6

8.3 ± 1.5**

8.0 ± 1.0

6.09 ± 0.8##

7.3 ± 0.6

5.6 ± 0.9##

FS (%)

55.6 ± 5.3

38.5 ± 7.8**

39.2 ± 4.9

52.0 ± 5.1##

46.1 ± 8.5

53.8 ± 6.1##††

  1. *p < 0.05, **p < 0.01 vs. Sham + vehicle group.
  2. #p < 0.05, ##p < 0.01 vs. TAC + vehicle group.
  3. †p < 0.05, ††p < 0.01 vs. TAC + CUR 1 mg/kg group.
  4. The values shown are the mean ± SEM for 6–7 mice from each of the sham and TAC groups.
  5. Abbreviations: LVPWd, left ventricular posterior wall thickness; IVSd, interventricular septum thickness at end-diastole; LVIDd, left ventricular internal diameter end-diastole; LVIDs, left ventricular internal diameter end-systole; LVMI, left ventricular mass index; FS, fractional shortening
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