Figure 2
From: SVF-derived extracellular vesicles carry characteristic miRNAs in lipedema
Analysis of microRNA (miRNA) signal origin. miRNAs signals obtained in small extracellular vesicles (sEVs) were compared against the total miRNA signal in concentrated conditioned medium (cCM) and expressed as %. (a) Top 20 miRNAs with highest EV-derived signal: Three miRNAs, for which more than 90% of the signal in cCM originated from the sEV enriched fraction (miR-144-3p, miR-144-5p, miR-190a-5p), and 6 further miRNAs where more than 50% of the signal was derived from the sEV fraction could be found. (b) Bottom 20 miRNAs with signals mostly derived from non-EV miRNAs: 83 out of 133 miRNAs were highly enriched in the non-sEV fraction as less than 10% of the total signal was obtained from the sEV fraction.The 20 miRNAs with the lowest signal, were below 4%.
