Figure 3
From: SVF-derived extracellular vesicles carry characteristic miRNAs in lipedema
Hierarchical clustering of samples based on microRNA (miRNA) profiles observed in concentrated conditioned medium (cCM) or small extracellular vesicles (sEVs) from control (co) and lipedema (lip). The 30 most variant (according to coefficient of variation) miRNAs in cCM (a) and sEVs (b) were used for clustering analysis (Pearson correlation, average linkage). Rows are centered and unit variance scaling is applied to the global mean normalized expression values. Color indicates relative up- (red) or down-regulation for each miRNA (row). There were no clusters corresponding to the groups in the cCM miRNA data (a), while in the sEV enriched miRNA data 2 control samples clustered and 2 lipedema samples clustered (b).
