Table 1 Obvious phenotypes in the CRISPR/Cas9 resource.

From: CRISPR/Cas9 mediated genetic resource for unknown kinase and phosphatase genes in Drosophila

Gene symbol

Human ortholog(*OMIM)

Phenotype

Predicted function

CG34380

DDR1*,2*

Lethal

Peptidyl-tyrosine phosphorylation

CG9222

TSSK1B*,2*,4*

Lethal

Protein serine/threonine kinase

CG7236

CDKL1*,2*,3*,5*

Lethal

Mitotic cytokinesis

CG33671

MVK*

Lethala

Isoprenoid biosynthetic process

CG10738

NPR1*,2*

Lethal

Positive regulation of cell proliferation

CG6767

PRPS1*, S1L1*

Lethal

Imaginal-disc drived wing morphogenesis

CG17028

IMPA1*,2*

Lethal b

Insitol phosphate dephosphorylation

CG9784

——

Lethal

Phosphatidylinositol dephosphorylation

CG34455

——

Lethal

Cellular response to monosaccharide

CG14305

TSSK1B*,2*,3*,6*

Male sterilea

Protein serine/threonine kinase

CG3608

ADCK1*

Female sterile#

Positive regulation of multicellular organism growth

CG4041

TBCK

Female sterile

Golgi organization

CG15743

IMPAD1*, UBE2W*

Female sterilea

Phosphatidylinositol biosynthetic process

  1. aThe lethality phenotype of CG33671 and male sterility phenotype of CG14305 both can be rescued by their own original genomic transcripts. bThe lethality phenotype of CG17028 cannot be rescued by its original genomic transcript. #The female sterility phenotype of CG3608 was observed from the in-frame mutant alleles, because we did not obtain frameshift mutant alleles for CG3608 in our resource.
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