Figure 4
Increases of GABA in the brain regions of SCR-KO mice. (a) Signal intensity of GABA in sagittal brain sections is represented on a green-color scale. The merged images of GABA (green) and Glu (magenta) show different distribution patterns of GABA and Glu in the brain sagittal sections. The brightness of the green areas in each brain region of the WT and SCR-KO mice is represented in histograms (scale bar, 2 mm). (b) The ratio of GABA signal intensity in each brain region between the SCR-KO and WT mice. As in Fig. 2b, the SCR-KO/WT intensity ratio of the geometric mean of the signal intensity histogram in each comparison is represented as a point (n = 5 mice); the geometric mean approximates to the peak of the histogram. The arithmetic mean and standard deviation of SCR-KO/WT intensity ratios is displayed as a bar. Asterisks indicate brain regions that featured significant differences (*p < 0.05) in the student’s t test between the SCR-KO/WT intensity ratio and the null distribution, which has a mean of 1 and the same standard deviation as that of the geometric mean distribution of each brain region.
