Table 2 Achieving remission according to Dtotal at diagnosis.

From: Impact of season on the association between vitamin D levels at diagnosis and one-year remission in early Rheumatoid Arthritis

 

Low Dtotal (<50 nmol/L)

Normal Dtotal (≥50 nmol/L)

Contrast between groups

Primary outcome: Remission. (%)

N = 45 (71%)

N = 51 (64%)

Crude analysisa:

OR 1.4, 95% CI (0.7; 2.7) p = 0.33

Logistic regressionb:

OR 1.4, 95% CI (0.7; 2.9) p = 0.34

Adjusted logistic regressionc:

OR 2.6, 95% CI (1.1; 5.9) p = 0.03

Best-case scenario assuming the 15 patients not evaluated for year on, all did achieved remission

N = 49 (73%)

N = 62 (68%)

Crude analysisa:

OR 1.3, 95% CI (0.6; 2.6) p = 0.50

Logistic regressionb:

OR 1.3, 95% CI (0.6; 2.6) p = 0.51

Adjusted logistic regressionc:

OR 2.0 95% CI (0.9, 4.3) p = 0.09

Worst-case scenario assuming the 15 patients not evaluated for year one, all did not achieved remission

N = 45 (67%)

N = 51 (56%)

Crude analysisa:

OR 1.6, 95% CI (0.8; 3.1) p = 0.16

Logistic regressionb:

OR 1.6, 95% CI (0.8; 3) p = 0.2

Adjusted logistic regressionc:

OR 2.9, 95% CI (1.3; 6.2) p = 0.01

Change in disease activity markers after 1 year according to Dtotal group at time of diagnosis

Change in HAQ

Mean: −0.6

95% CI (−0.7; −0.5)

Mean: −0.6

95% CI (−0.7; −0.5)

Least Squares Mean Difference:

Crude analysis: −0.1, 95% CI (−0.2;0.1) p = 0.48

Change in NTJ

Mean: −9.7

95%CI (−10.9; 8.8)

Mean: −8.6

95% CI (−9.5; 7.8)

Least Squares Mean Difference:

Crude analysis: 1.1, 95% CI (−0.2; 2.4) p = 0.09

Change in NSJ

Mean: −8.8

95% CI (−9.3; −8.3)

Mean: −8.1

95% CI (−8.1; −7.7)

Least Squares Mean Difference:

Crude analysis: 0.7, 95% CI (0.0; 1.3) p = 0.04

Change in VASdoctor global

Mean: −47.7

95% CI (−51; −44.4)

Mean: −44.7

95% CI (−47.5; −41.8)

Least Squares Mean Difference:

Crude analysis: 3.2, 95% CI (−1.3; 7.5) p = 0.17

Change in VASpatient-pain

Mean: −29.7

95% CI (−34.9; −24.5)

Mean: −28.2

95% CI (−32.7; −23.6)

Least Squares Mean Difference:

Crude analysis: 1.6, 95% CI (−5.3; 8.5) p = 0.65

Change in VASpatient global

Mean: −31.6

95% CI (−37; −26.2)

Mean: −28.9

95% CI (−33.7; −24.1)

Least Squares Mean Difference:

Crude analysis: 2.7, 95% CI (−4.5; 10) p = 0.46

Change in ESR, mm/hour

Mean: −12.8

95% CI (−16.3; −9.3)

Mean: −14.2

95% CI (−17.3; −11.1)

Least Squares Mean Difference:

Crude analysis: −1.4, 95% CI (−6.2; 3.3) p = 0.55

Change in CRP, mg/l

Mean: −21.1

95% CI (−25.2; −16.9)

Mean: −20.4

95% CI (−24.1; −16.7)

Least Squares Mean Difference:

Crude analysis: 0.6, 95% CI (−4.9; 6.2) p = 0.82

Change in DAS28-CRP

Mean: −3

95% CI (−3.3; −2.7)

Mean: −2.7

95% CI (−2.9; −2.4)

Least Squares Mean Difference:

Crude analysis:0.3, 95% CI (−0.1; 0.7) p = 0.08

  1. aCrude logistic regression; Dtotal group as independent variable, no other covariates.
  2. bSimple logistic regression, further containing age at diagnosis and sex.
  3. cMultiple logistic regression, further adjusted for symptom-duration prior to diagnosis, DAS28-CRP at diagnosis and diagnosis established in winter (November to April).
  4. For all comparisons, the group having normal Dtotal (i.e defined as “not low”) is the reference.
  5. Abbreviations: Dtotal: The sum of 25OHD2 and 25OHD3. BMI: Body Mass Index, ACPA: Anti Citrullinated Protein Antibodies, IgM-RF: Immunoglobulin M Rheumafactor, NTJ: Number of Tender Joints, NSJ: Number of Swollen Joints, VAS: Visual Analogue Score, HAQ: Health Assessment Questionnaire, CRP: C-reactive protein, DAS28-CRP Disease Activity Score, based on 28 joint count and CRP.
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