Figure 1 | Scientific Reports

Figure 1

From: Tumor grafts grown on the chicken chorioallantoic membrane are distinctively characterized by MRI under functional gas challenge

Figure 1

(A) In ovo MRI images of A549 lung adenocarcinoma and MC-38 colon carcinoma cell grafts grown on the CAM of the chicken embryo for 7 days. Grafts are shown in T1w and T2w anatomical reference images and are outlined with regions of interest on quantitative color-coded T1 (qT1) and T2* (qT2*) maps obtained while the graft was exposed to medical air and carbogen, respectively. (B) Comparative histology. Shown are sample slices from both graft types stained for H&E (top) and Ki-67 (bottom), respectively. Inserts: Supportive plastic ring with the graft (arrowhead) on the CAM, photographed after extraction of the CAM. Both graft types display distinct phenotypes with regards to cellularity (H&E) and proliferative status (Ki-67). (C) Graft size comparison. Quantitative comparison of graft diameter between A549 lung adenocarcinoma and MC-38 colon carcinoma cell grafts. (D) Vessel density comparison. Quantitative comparison of vessel density in A549 and MC-38 cell grafts.

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