Figure 5
From: Polymorphisms in miRNA binding sites involved in metabolic diseases in mice and humans
Networks of miRNA binding sites (blue), harboring a polymorphism in 26 target genes (light blue) that are associated to a metabolically relevant phenotype as indicated in the corresponding knockout mouse (white), the phenotype in GWAS (light grey) or an eQTL (grey). If experimental evidence for a miRNA-mRNA binding site exists, the edge is illustrated in red. (a) Association of Arhgef40 to abnormal body fat amount, Cd14 to abnormal cytokine secretion and Dock5 to glucose homeostasis. (b) Complex network linked to an altered glucose tolerance and increased fat mass. (c) Network, divided in subnetworks related to (i) increased body fat and glucose levels, (ii) GWAS of BMI and obesity, (iii) increased body weight and (iv) to cholesterol GWAS and eQTL of visceral adipose tissue or muscle.
