Figure 1 | Scientific Reports

Figure 1

From: Enhanced Cerebral Blood Volume under Normobaric Hyperoxia in the J20-hAPP Mouse Model of Alzheimer’s Disease

Figure 1

Representative 2D-OIS haemodynamic data from an AD mouse to a 2s-mechanical whisker stimulation. Top: chronic imaging sessions. Bottom: Acute imaging sessions with electrode. (A) Raw grayscale image of thinned cranial window overlaid with the active region of interest (ROI; red) as defined from B. (B) Spatial map of HbT activation across a stimulation trial with colour-bar representing the % change of HbT from baseline. (C) Vessel map showing arteries and veins within the window and active ROI. (D) Time-series profiles of the haemodynamic data showing increases to HbT & HbO and a decrease (washout) in HbR. Dotted lines represent start and end time of whisker stimulation.

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