Figure 4
Average gas transitions between hyperoxic and normoxic conditions in WT and J20-hAPP mice. (A) Time-series of gas transition experiments: top; transition from 100% oxygen to 21% oxygen & bottom; transition from 21% oxygen to 100% oxygen. (B) Time-series of HbT at baseline at 100% oxygen and during gas transition to 21% oxygen with % change in HbT: WT-HbT 0.5%±1.8%STD, J20-HbT 6.2%%±3%STD. Error bars ± SEM. (C) Representative spatial map showing the differences in HbT across all vascular compartments in a J20-hAPP mouse (bottom), but not WT mouse (top) under normobaric hyperoxia.
