Figure 4 | Scientific Reports

Figure 4

From: IFN-γ and IgG responses to Mycobacterium tuberculosis latency antigen Rv2626c differentiate remote from recent tuberculosis infection

Figure 4

Antibody responses to Rv2626c antigen in plasma from individuals highly exposed to Mycobacterium tuberculosis. (a) Samples from CC, HW and TB patients were collected and total IgG responses were measured by ELISA. Each symbol represents the levels of anti-Rv2626c IgG per individual (ng/mL). Mean ± SEM for each group of subjects is shown. **P < 0.01, ****P < 0.0001. P-values were calculated by Kruskal-Wallis test and Dunn’s multiple comparisons post-test for unpaired samples. The horizontal dotted line indicates the IgG ELISA cut-off (10 ng/mL). (b) ROC (Receiver Operating Characteristic) analysis for IgG responses to Rv2626c was performed to evaluate its potential use in discriminating LTBI (HW QFT positive) from other Mtb exposed individuals (CC QFT positive and QFT negative and TB). AUC = 0.9186; P < 0.0001; 95% CI: 0,8358–1,001.

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