Table 5 PARP1 genotypes and hematological toxicities.
Variables | Neutropenia | Thrombocytopenia | Anemia | |||
|---|---|---|---|---|---|---|
Rs1136410 | P | HR (95%CI) | P | HR (95%CI) | P | HR (95%CI) |
TT | 1(Ref) | 1(Ref) | 1(Ref) | |||
TC | 0.635 | 0.880 (0.519–1.492) | 0.212 | 0.521 (0.187–1.451) | 0.832 | 0.895 (0.321–2.494) |
CC | 0.550 | 0.803 (0.392–1.646) | 0.477 | 1.491 (0.496–4.487) | 0.067 | 2.762 (0.932–8.183) |
rs11801168 | ||||||
TT | 1(Ref) | 1(Ref) | 1(Ref) | |||
TC | 0.991 | 1.009 (0.209–4.859) | 0.845 | 0.800 (0.085–7.529) | 0.640 | 0.581 (0.060–5.659) |
CC | 0.644 | 0.699 (0.152–3.203) | 0.443 | 0.424 (0.047–3.789) | 0.609 | 0.567 (0.064–4.986) |
Rs12568297 | ||||||
GG | 1(Ref) | 1(Ref) | 1(Ref) | |||
GC | 0.442 | 1.301 (0.666–2.541) | 0.269 | 1.823 (0.629–5.286) | 0.378 | 1.605 (0.560–4.596) |
CC | 0.646 | 1.527 (0.250–9.312) | 0.301 | 3.281 (0.346–31.116) | 0.354 | 2.889 (0.306–27.234) |
Rs6664761 | ||||||
TT | 1(Ref) | 1(Ref) | 1(Ref) | |||
TC | 0.370 | 1.427 (0.655–3.108) | 0.313 | 2.936 (0.362–23.808) | 0.313 | 2.936 (0.362–23.808) |
CC | 0.307 | 1.500 (0.689–3.265) | 0.270 | 3.229 (0.402–25.971) | 0.199 | 3.888 (0.490–30.870) |
Rs7531668 | ||||||
TT | 1(Ref) | 1(Ref) | 1(Ref) | |||
TA | 0.900 | 0.966 (0.563–1.658) | 0.698 | 0.822 (0.306–2,208) | 0.500 | 0.716 (0.271–1.893) |
AA | 0.299 | 0.663 (0.305–1.441) | 0.290 | 0.329 (0.042–2.585) | 0.233 | 0.286 (0.037–2.234) |
