Figure 4
From: Metabolic and Non-metabolic Roles of Pyruvate Kinase M2 Isoform in Diabetic Retinopathy

Levels of pyruvate kinase and lactate in db/db mice. Pyruvate kinase activity (PK) was measured with an LDH-coupled enzyme assay in the presence of 0.5 mM PEP (A). Lactate levels were measured using the lactate oxidase method (B). Data are mean + SEM (n = 6). *p < 0.0001; n.s., no significance.