Figure 6
Metabolites that are enriched in pups’ sera relative to that of their respective mothers. Citrulline is a precursor to arginine, an intermediate in the urea cycle, and a by-product in the enzymatic production of nitric oxide from arginine by nitric oxide synthase. Pyridoxine (Vitamin B6) is required for synthesis of amino acids, carbohydrates, lipids, and haemoglobin, for which it is also involved in modifying haemoglobin’s affinity for oxygen. Adenosine is a component of nucleic acids and intermediates in energy metabolism such as ATP, but is also a neuromodulator and active in vasodilation. NMPC, N1-Methyl-2-pyridone-5-carboxamide. Detailed box and whisker plots of the data also showing individual ratio values are given in Supplementary Figure S10. See Supplementary Table S1 for full statistical analysis of where significant differences were found between the days for each of the compounds. See legend for Fig. 5 for details of how the data are calculated and presented.
