Table 3 Crude and adjusted hazard ratios and 95% confidence intervals (CI) from Cox proportional hazard regression analysis for corneal ulcer during the follow-up period in the study cohort.

From: Risk of Corneal Ulcer in Patients with Diabetes Mellitus: A Retrospective Large-Scale Cohort Study

 

Crude hazard ratio (95% CI)

Adjusted hazard ratio (95% CI)

DM

Yes

1.29* (1.22-1.37)

1.31* (1.24-1.40)

No

1.00

1.00

Age at index date

20–50

1.18* (1.10-1.28)

1.15* (1.06-1.25)

50–64

1.05 (0.97-1.13)

1.03 (0.95-1.12)

≥65

1.00

1.00

Sex

Male

1.15* (1.08-1.22)

1.14* (1.08-1.21)

Female

1.00

1.00

Baseline comorbidities

HTN

Yes

0.96 (0.89-1.03)

0.93 (0.86-1.01)

No

1.00

1.00

HPL

Yes

1.01 (0.90-1.14)

0.97 (0.85-1.09)

No

1.00

1.00

CHF

Yes

0.92 (0.71-1.19)

0.92 (0.71-1.20)

No

1.00

1.00

CAD

Yes

0.98 (0.86-1.11)

1.00 (0.88-1.15)

No

1.00

1.00

CRD

Yes

1.04 (0.81-1.33)

1.04 (0.81-1.34)

No

1.00

1.00

  1. Note: The adjusted hazard ratio for developing corneal ulcer was calculated using a Cox proportional hazard regression analysis.
  2. Abbreviations: DM, diabetes mellitus; HTN, hypertension; HPL, hyperlipidemia; CHF, congestive heart failure; CAD, coronary heart disease; CRD, chronic renal disease.
  3. *P-value <0.05.