Table 2 Serum neurofilament light chain levels at baseline, 3 months, and 6 months of treatment according to neuropathy grade at 6 months of treatment, adjusted for age.

From: Serum neurofilament light chain levels as a biomarker of neuroaxonal injury and severity of oxaliplatin-induced peripheral neuropathy

 

OIPN grade 0–1 (n = 10)

OIPN grade 2 (n = 19)

OIPN grade 3 (n = 5)

Post-hoc p-value (Bonferroni)

Adjusted mean

95% CI

Adjusted mean

95% CI

Adjusted mean

95% CI

OIPN gr 0–1 vs 2

OIPN gr 2 vs 3

OIPN gr 1 vs 3

sNfL at baseline (pg/mL)

14.1

4.6, 23.5

20.1

13.2, 26.9

16.1

2.7, 29.5

0.907

1.0

1.0

sNfL at 3 months (pg/mL)

21.2

15.2, 27.2

26.0

21.7, 30.4

25.8

17.4, 30.4

0.575

1.0

1.0

sNfL at 6 months (pg/mL)

91.6

38.9, 144.2

127.0

89.1, 165.0

373.4

298.8, 447.9

0.820

<0.001

<0.001

  1. Abbreviations: OIPN, oxaliplatin-induced peripheral neuropathy; gr, grade; sNfL, serum neurofilament light chain; CI, confidence interval.
  2. p-values <0.05 are shown in bold.
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