Table 2 Associations between genetic predictors for selected risk factors and LV mass, by sex.
From: The polygenic architecture of left ventricular mass mirrors the clinical epidemiology
Risk factor | Males | P-value | Females | P-value |
|---|---|---|---|---|
Change in LV Massa | Change in LV Massa | |||
Inverse-variance weighted average meta-analysis | ||||
Body mass index | 0.079 (0.015) | 1.2 × 10−7 | 0.147 (0.016) | 1.7 × 10−20 |
Systolic blood pressure | 0.004 (0.002) | 0.03 | 0.001 (0.001) | 0.29 |
Coronary artery disease | 0.027 (0.013) | 0.03 | −0.002 (0.014) | 0.87 |
Type 2 diabetes (T2D) | −0.001 (0.008) | 0.92b | 0.018 (0.008) | 0.02 |
T2D, excluding BMI SNPsd | 0.017 (0.015) | 0.25 | −0.008 (0.015) | 0.62 |
MR-Egger method | ||||
Body mass index | 0.146 (0.047) | 0.002 | 0.168 (0.050) | 0.001 |
Systolic blood pressure | 0.002 (0.007) | 0.7 | 0.000 (0.007) | 0.95 |
Coronary artery disease | 0.044 (0.030) | 0.15 | −0.040 (0.033) | 0.23 |
Type 2 diabetes (T2D) | −0.042 (0.018) | 0.02c | 0.004 (0.019) | 0.82 |
T2D, excluding BMI SNPsd | −0.026 (0.046) | 0.58 | 0.049 (0.049) | 0.31 |
Weighted median method | ||||
Body mass index | 0.114 (0.025) | 4.0 × 10−6 | 0.145 (0.029) | 6.8 × 10−7 |
Systolic blood pressure | 0.003 (0.003) | 0.24 | −0.002 (0.003) | 0.51 |
Coronary artery disease | 0.037 (0.020) | 0.06 | −0.020 (0.022) | 0.37 |
Type 2 diabetes (T2D) | −0.017 (0.014) | 0.23 | 0.008 (0.015) | 0.6 |
T2D, excluding BMI SNPsd | 0.006 (0.023) | 0.81 | −0.003 (0.025) | 0.9 |
