Table 4 Comparison of Activity of BsAbs.
Binding Domain | No. Abs | Avg. Kd (nM) | Average Cytotoxicity (EC50, nM) | Average max. cytotoxicity (%) | Avg. T cell activation (EC50, nM) | Average max. T cell activation (%) |
|---|---|---|---|---|---|---|
1 | 1 | 1.6 | 0.15 | 58 | 0.1 | 85 |
2 | 12 | 1.1 | 0.76 | 58 | 0.7 | 82 |
3 | 10 | 0.41 | 0.22 | 64 | 0.1 | 88 |
4 | 12 | 0.95 | 0.70 | 57.1 | 0.3 | 85 |
5 | 0 | NA | NA | NA | NA | NA |
6 | 1 | 3.5 | 0.36 | 63 | 0.15 | 88 |
